Blar i forfatter "Totland, Max"

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    • Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases 

      Kryeziu, Kushtrim; Moosavi, Seyed Hossein; Bergsland, Christian Holst; Guren, Marianne; Eide, Peter Andreas Wold; Totland, Max; Lassen, Kristoffer; Abildgaard, Andreas; Nesbakken, Arild; Sveen, Anita; Lothe, Ragnhild Adelheid (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-08)
      Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses ex vivo and ofer an opportunity to evaluate novel treatment strategies in a personalized fashion. Here we have evaluated spatio-temporal functional and molecular dynamics of fve PDO models ...

    • Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications 

      Totland, Max; Rasmussen, Nikoline Lander; Knudsen, Lars Mørland; Leithe, Edward (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-09)
      Gap junctions consist of arrays of intercellular channels that enable adjacent cells to communicate both electrically and metabolically. Gap junctions have a wide diversity of physiological functions, playing critical roles in both excitable and non-excitable tissues. Gap junction channels are formed by integral membrane proteins called connexins. Inherited or acquired alterations in connexins are ...